F0 and F1 generation further presented with syringomyelia (F0: C4-D1 F1: C4-D2). In this study, three generations of a family suffering from Chiari 1 or Chiari 0 malformation have been examined with MRI, clinically and laboratory (hemograms).Ĭhiari malformation could be confirmed in all presented patients: While the F2 generation (children: 1 × ♀, 1 × ♂) and the female F1 generation (mother and sister of mother) suffered from Chiari type 1, the male F0 generation showed Chiari 0 malformation. Furthermore, an association of Chiari disorder and vitamin B12 deficit has rarely been described in literature. Documented cases of familial Chiari malformation in three consecutive generations are rare. Some associations between this disorder and genetical variations have been reported.
A clear etiology of Chiari malformation is still lacking.
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